Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12558144 | 0.94 | NPC1 (0.58) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL10197815 | 0.86 | MAPT (0.58) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL15886277 | 0.85 | NPC1 (0.57) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL24060059 | 0.84 | RAB9A (0.72) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL12764175 | 0.83 | RAB9A (0.74) | NPC1RAB9AKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL15886244 | 0.81 | NAMPT (0.56) | NPC1RAB9ASMN1; SMN2NPSR1LMNA | |
| SCHEMBL24746420 | 0.81 | SMN1; SMN2 (0.59) | NPC1RAB9AKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL1749832 | 0.81 | HPGD (0.54) | NPC1KDM4ESMN1; SMN2NPSR1LMNA | |
| SCHEMBL2241850 | 0.81 | ALDH1A1 (0.60) | NPC1KDM4ESMN1; SMN2TSHRLMNA | |
| SCHEMBL30976769 | 0.81 | HPGD (0.58) | NPC1KDM4ESMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |