Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | GCKR | Q14397 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316003 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNA4MCHR1HRH3DPP4 | |
| SCHEMBL23089626 | 0.85 | PIK3CA (0.41) | CHRNB2CHRNA4HRH3DPP4DPP8 | |
| SCHEMBL29814607 | 0.85 | PIK3CA (0.41) | CHRNB2CHRNA4HRH3DPP4DPP8 | |
| SCHEMBL23089627 | 0.85 | PIK3CA (0.41) | CHRNB2CHRNA4HRH3DPP4DPP8 | |
| SCHEMBL24746028 | 0.84 | CHRNB2 (0.41) | CHRNB2CHRNA4HRH3DPP4DPP8 | |
| SCHEMBL25558878 | 0.81 | DPP4 (0.41) | CHRNB2CHRNA4DPP4DPP8DPP9 | |
| SCHEMBL29814459 | 0.80 | PIK3CA (0.37) | CHRNB2CHRNA4HRH3PIK3CAMTOR | |
| SCHEMBL23089168 | 0.80 | PIK3CA (0.37) | CHRNB2CHRNA4HRH3PIK3CAMTOR | |
| SCHEMBL31607811 | 0.79 | TRPC6 (0.39) | CHRNB2CHRNA4HRH3DPP4DPP8 | |
| SCHEMBL26641428 | 0.79 | TRPC6 (0.39) | CHRNB2CHRNA4HRH3DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |