Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ebastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.91 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.91 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.91 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.91 |
| ▸ | NPC1 | O15118 | 1/20 | 0.91 |
| ▸ | MLNR | O43193 | 1/20 | 0.91 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.91 |
| ▸ | EGFR | P00533 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.91 |
| ▸ | FYN | P06241 | 1/20 | 0.91 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.91 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.91 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.91 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.91 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ebastine SCHEMBL28531760 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL25199696 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL2475734 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL25207151 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL18467 | 0.95 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Fumaric Acid SCHEMBL10766545 | 0.95 | DRD2 (0.82) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Fumaric Acid SCHEMBL10766542 | 0.95 | DRD2 (0.82) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL25205252 | 0.94 | ADRA1D (0.98) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL2546560 | 0.93 | ADRA1D (0.96) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| SCHEMBL1362953 | 0.92 | ADRA1D (0.94) | ADRA1DADRA1AADRA1BNPC1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574097-B | Preparation method of Ebastine and fumarate thereof | 杭州仟源保灵药业有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-112574097-A | Preparation method of Ebastine and fumarate thereof | 杭州仟源保灵药业有限公司 | 2021-03-30 | — | — | CN | claimed |
| WO-2012076919-A1 | PROCESS OF PREPARING EBASTINE | MICRO LABS LIMITED (IN) | 2012-06-14 | — | — | WO | claimed |
| WO-2009157006-A1 | PROCESS OF PREPARING EBASTINE | MICRO LABS LIMITED (IN) | 2009-12-30 | — | — | WO | claimed |
| CN-118718873-A | A mud prilling granulator for pharmaceutical chemical production | 江苏联环药业股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-112574097-B | Preparation method of Ebastine and fumarate thereof | 杭州仟源保灵药业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-112574097-A | Preparation method of Ebastine and fumarate thereof | 杭州仟源保灵药业有限公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2012076919-A1 | PROCESS OF PREPARING EBASTINE | MICRO LABS LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011121099-A2 | PROCESS FOR THE PREPARATION OF 1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-[4-(DIPHENYLMETHOXY)-1-PIPERIDINYL]-1-BUTANONE AND ACID ADDITION SALTS THEREOF | AREVIPHARMA GMBH (DE) | 2011-10-06 | — | — | WO | disclosed |
| EP-2371817-A1 | Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof | Arevipharma GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |
| WO-2009157006-A1 | PROCESS OF PREPARING EBASTINE | MICRO LABS LIMITED (IN) | 2009-12-30 | — | — | WO | disclosed |
| EP-0134124-B1 | PIPERIDINE DERIVATIVES | FORDONAL, S.A. (ES) | 1987-10-28 | — | — | EP | disclosed |
| US-4550116-A | ANTIALLERGENS, CARDIOVASCULAR AND RESPIRATORY DISORDERS | FORDONAL, S.A. (ES) | 1985-10-29 | — | — | US | disclosed |
| EP-0134124-A1 | Piperidine derivatives | FORDONAL, S.A. (ES) | 1985-03-13 | — | — | EP | disclosed |