Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ebastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.91 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.91 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.91 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.91 |
| ▸ | NPC1 | O15118 | 1/20 | 0.91 |
| ▸ | MLNR | O43193 | 1/20 | 0.91 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.91 |
| ▸ | EGFR | P00533 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.91 |
| ▸ | FYN | P06241 | 1/20 | 0.91 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.91 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.91 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.91 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.91 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ebastine SCHEMBL2475732 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL28531760 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL2475734 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL25207151 | 1.00 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL18467 | 0.95 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Fumaric Acid SCHEMBL10766545 | 0.95 | DRD2 (0.82) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Fumaric Acid SCHEMBL10766542 | 0.95 | DRD2 (0.82) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL25205252 | 0.94 | ADRA1D (0.98) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| Ebastine SCHEMBL2546560 | 0.93 | ADRA1D (0.96) | ADRA1DADRA1AADRA1BNPC1MLNR | |
| SCHEMBL1362953 | 0.92 | ADRA1D (0.94) | ADRA1DADRA1AADRA1BNPC1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023087611-A1 | SALT OF EBASTINE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏联环药业股份有限公司 | 2023-05-25 | — | — | WO | disclosed |
| CN-114712322-A | Tablet of ebastine salt and preparation method thereof | 南京联智医药科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114681400-A | Salt oral solution preparation containing ebastine and preparation method thereof | 南京联智医药科技有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-114014796-A | Epstein salt and preparation method and application thereof | 江苏联环药业股份有限公司 | 2022-02-08 | — | — | CN | disclosed |