Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474761 | 0.88 | RAB9A (0.60) | NPC1RAB9ATP53SMN1; SMN2NAMPT | |
| SCHEMBL2476936 | 0.85 | NPC1 (0.64) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL16564460 | 0.82 | BAZ1A (0.42) | TRPV1NPC1RAB9AMAPTLMNA | |
| SCHEMBL2476185 | 0.81 | CA12 (0.55) | TRPV1NPC1RAB9ASMN1; SMN2NAMPT | |
| SCHEMBL20271463 | 0.79 | TRPV1 (0.63) | TRPV1KCNH2HPGDSNPC1RAB9A | |
| SCHEMBL2476567 | 0.78 | TSHR (0.56) | TRPV1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2480782 | 0.78 | NPC1 (0.56) | TRPV1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL13504385 | 0.75 | SLC9A1 (0.43) | TRPV1GAA | |
| SCHEMBL13504389 | 0.75 | SLC9A1 (0.43) | TRPV1GAA | |
| SCHEMBL2477318 | 0.75 | GFER (0.47) | SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373620-A1 | NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2011-10-12 | — | — | EP | disclosed |