Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708672 | 0.87 | ADRA1A (0.58) | ADRA1ASLC6A3CHRM2HTR1AADRA2A | |
| SCHEMBL12198408 | 0.83 | NPC1 (0.47) | KDM4EMEN1LMNAKMT2AHDAC1 | |
| SCHEMBL2444789 | 0.82 | MAPT (0.56) | ADRA1ASLC6A3CHRM2HTR1AADRA2A | |
| SCHEMBL25538790 | 0.81 | TDP1 (0.52) | ADRA1ASLC6A3CHRM2ADRA2ADRD1 | |
| SCHEMBL3364898 | 0.77 | NPC1 (0.52) | KDM4EMEN1LMNAKMT2AHDAC1 | |
| SCHEMBL15062794 | 0.77 | ALOX5 (0.56) | HDAC1HDAC2HDAC8ALOX5 | |
| SCHEMBL2443821 | 0.77 | KEAP1 (0.54) | ADRA1ASLC6A3CHRM2ADRA2ADRD1 | |
| SCHEMBL5085940 | 0.77 | TDP1 (0.64) | ADRA1ASLC6A3CHRM2ADRA2ADRD1 | |
| SCHEMBL5852270 | 0.77 | TDP1 (0.64) | ADRA1ASLC6A3CHRM2ADRA2ADRD1 | |
| SCHEMBL13129733 | 0.77 | TDP1 (0.64) | ADRA1ASLC6A3CHRM2ADRA2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |
| WO-2011107948-A2 | LIGANDS OF INSULIN DEGRADING ENZYME AND THEIR USES | UNIVERSITE LILLE 2 DROIT ET SANTE (FR) | 2011-09-09 | — | — | WO | disclosed |