Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.35 |
| ▸ | CSF3R | Q99062 | 1/20 | 0.35 |
| ▸ | KYNU | Q16719 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GGH | Q92820 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740013 | 0.89 | ALDH1A1 (0.55) | ALDH1A1CYP3A4HPGDSTSHRHTR7 | |
| SCHEMBL2135627 | 0.75 | ALDH1A1 (0.53) | ALDH1A1CYP3A4TSHRHTR7 | |
| SCHEMBL8084726 | 0.73 | ALDH1A1 (0.59) | ALDH1A1CYP3A4TSHRHTR7CA12 | |
| SCHEMBL342130 | 0.73 | ALDH1A1 (0.58) | ALDH1A1CYP3A4TSHRKDM4ECA12 | |
| SCHEMBL2808504 | 0.72 | RAB9A (0.46) | ALDH1A1CYP3A4FFAR1 | |
| SCHEMBL22716240 | 0.72 | FOLH1 (0.39) | ALDH1A1TSHRFFAR1 | |
| SCHEMBL11879900 | 0.72 | FFAR1 (0.43) | ALDH1A1CYP3A4TSHRFFAR1 | |
| SCHEMBL2808540 | 0.72 | PTPN1 (0.46) | ALDH1A1MEP1BCA12CA1CA2 | |
| SCHEMBL29415443 | 0.72 | RAB9A (0.46) | ALDH1A1CYP3A4FFAR1 | |
| SCHEMBL2804456 | 0.72 | SMN1; SMN2 (0.47) | ALDH1A1CYP3A4TSHRFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387602-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387602-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | JMJD7, MDM2, IDE | ALDH1A1 2189/4885CYP3A4 2539/4885HPGDS 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.