SCHEMBL24784337

SCHEMBL24784337

CC(C)N1C(=O)c2cccc3c(N(C)C)ccc(c23)C1=O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 12/20 0.70
▸ MEN1 O00255 10/20 0.70
▸ POLB P06746 4/20 0.70
▸ USP2 O75604 7/20 0.63
▸ ALDH1A1 P00352 7/20 0.43
▸ MAPT P10636 6/20 0.43
▸ CASP1 P29466 3/20 0.43
▸ CASP7 P55210 3/20 0.43
▸ HBB P68871 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ GAA P10253 2/20 0.43
▸ CRHBP P24387 1/20 0.43
▸ BRCA1 P38398 1/20 0.43
▸ CRHR2 Q13324 1/20 0.43
▸ KDM4E B2RXH2 6/20 0.42
▸ KEAP1 Q14145 5/20 0.42
▸ NFE2L2 Q16236 5/20 0.42
▸ HPGD P15428 2/20 0.42
▸ ATM Q13315 2/20 0.42
▸ HTT P42858 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25862810 0.83 KMT2A (0.51) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL11484431 0.83 KMT2A (1.00) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL1106641 0.83 KMT2A (0.65) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL12641677 0.82 MEN1 (0.58) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL2029464 0.81 KMT2A (0.74) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL19423810 0.81 KMT2A (0.74) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL10313084 0.79 KMT2A (0.70) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL28085238 0.79 KMT2A (0.70) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL16085320 0.78 USP2 (0.69) KMT2AMEN1POLBUSP2ALDH1A1
SCHEMBL12581330 0.78 KMT2A (1.00) KMT2AMEN1POLBUSP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220402963-A1 NUCLEOTIDE PROBES Sony Group Corporation (JP) 2022-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402963-A1 NUCLEOTIDE PROBES METTL3, SNRPA, L3MBTL3 KMT2A 1141/4885MEN1 1062/4885POLB 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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