Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.95 |
| ▸ | ARG2 | P78540 | 4/20 | 0.61 |
| ▸ | ARG1 | P05089 | 3/20 | 0.57 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.56 |
| ▸ | NOS2 | P35228 | 4/20 | 0.53 |
| ▸ | NOS1 | P29475 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | GGT1 | P19440 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL875015 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL706905 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL16893975 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL8029574 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL41761 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1191963 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL10582149 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL9762590 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL41760 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL30928253 | 1.00 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075280-B1 | HEMOGLOBIN-HAPTOGLOBIN COMPLEXES FOR TARGETED DRUG DELIVERY | THERAPURE BIOPHARMA INC (CA) | 2016-08-24 | — | — | EP | disclosed |
| US-20110237670-A1 | IMPROVEMENT OF NORMAL COGNITIVE FUNCTION | COGNITE AB (SE) | 2011-09-29 | — | — | US | disclosed |
| US-20090023632-A1 | Hemoglobin-haptoglobin complexes | HEMOSOL, INC. (CA) | 2009-01-22 | — | — | US | disclosed |
| US-20030013642-A1 | Hemoglobin-haptoglobin complexes | HEMOSOL, INC. | 2003-01-16 | — | — | US | disclosed |
| US-6479637-B1 | Hemoglobin-haptoglobin complexes | HEMSOL INC. (CA) | 2002-11-12 | — | — | US | disclosed |
| EP-1075280-A2 | HEMOGLOBINE-HAPTOGLOBIN COMPLEXES FOR TARGETED DURG DELIVERY | HEMOSOL INC. (CA) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999056723-A2 | HEMOGLOBINE-HAPTOGLOBIN COMPLEXES FOR TARGETED DRUG DELIVERY | HEMOSOL INC. (CA) | 1999-11-11 | — | — | WO | disclosed |
| EP-0592521-A4 | MONOCLONAL ANTIBODIES SPECIFIC FOR MARROW-DERIVED MESENCHYMAL CELLS. | CAPLAN ARNOLD I (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0592521-A1 | MONOCLONAL ANTIBODIES SPECIFIC FOR MARROW-DERIVED MESENCHYMAL CELLS | CAPLAN, Arnold I. (US) | 1994-04-20 | — | — | EP | disclosed |
| WO-1992022584-A1 | MONOCLONAL ANTIBODIES SPECIFIC FOR MARROW-DERIVED MESENCHYMAL CELLS | CAPLAN ARNOLD I (US) | 1992-12-23 | — | — | WO | disclosed |
| US-4713245-A | HEAT TREATMENT FORMS PROTECTIVE COATING DISSOLVING IN ACIDIC CONDITIONS | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1987-12-15 | — | — | US | disclosed |