Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15904697 | 0.87 | KDM4E (0.45) | NOTUMKDM4EUSP2HPGDNPSR1 | |
| SCHEMBL15903964 | 0.81 | NOTUM (0.50) | NOTUMKDM4ECYP2C19 | |
| SCHEMBL2480403 | 0.79 | CASP6 (0.42) | KDM4EHPGDCYP2C19 | |
| SCHEMBL2480196 | 0.74 | FAAH (0.32) | — | |
| SCHEMBL15903928 | 0.73 | ALDH1A1 (0.47) | NOTUMKDM4EHSD17B10 | |
| SCHEMBL2480855 | 0.71 | HRH3 (0.34) | — | |
| SCHEMBL1900342 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL695794 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL2484178 | 0.71 | FASN (0.40) | — | |
| SCHEMBL2480266 | 0.70 | AKR1C3 (0.42) | KDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376494-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010067888-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |