Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480403 | 0.81 | CASP6 (0.42) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL6639795 | 0.80 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1NAMPTMAPT | |
| SCHEMBL2480266 | 0.76 | AKR1C3 (0.42) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL2479566 | 0.74 | SMO (0.37) | MEN1KMT2AHTTMAPT | |
| SCHEMBL2481886 | 0.72 | NAMPT (0.42) | NAMPTMAPT | |
| SCHEMBL2481612 | 0.71 | KDM4E (0.40) | ALDH1A1MAPT | |
| SCHEMBL2480196 | 0.70 | FAAH (0.32) | MEN1KMT2ANPC1 | |
| SCHEMBL2476107 | 0.68 | CHRNA7 (0.42) | KMT2AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL695794 | 0.68 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL1900342 | 0.68 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376494-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010067888-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |