Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 6/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10038443 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL21769329 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL4813368 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL423924 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL4813371 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL11248300 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL11248303 | 0.85 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL10286412 | 0.84 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL21348602 | 0.84 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL12654818 | 0.84 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230139516-A1 | RIPK2 INHIBITION FOR THE TREATMENT OF CANCER | CEDARS-SINAI MEDICAL CENTER (US) | 2023-05-04 | — | — | US | disclosed |
| EP-4127216-A1 | RIPK2 INHIBITION FOR THE TREATMENT OF CANCER | Cedars-Sinai Medical Center (US) | 2023-02-08 | — | — | EP | disclosed |
| US-11161888-B2 | Method for regulating targeting of Cyclin Y (CCNY) protein to synapses | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-11-02 | — | — | US | disclosed |
| WO-2021202428-A1 | RIPK2 INHIBITION FOR THE TREATMENT OF CANCER | CEDARS-SINAI MEDICAL CENTER (US) | 2021-10-07 | — | — | WO | disclosed |
| US-20200408766-A1 | Palmitoyl Protein Biomarkers in Purified Extracellular Vesicles for Early Identification of Clinically Significant Prostate Cancer | CEDARS-SINAI MEDICAL CENTER (US) | 2020-12-31 | — | — | US | disclosed |
| US-10781471-B2 | NRAS related cancer therapy | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2020-09-22 | — | — | US | disclosed |
| US-20200140507-A1 | METHOD FOR REGULATING TARGETING OF NOVEL SYNAPTIC PROTEIN, CCNY PROTEIN, TO SYNAPSES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2020-05-07 | — | — | US | disclosed |
| US-20190151258-A1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES | 2019-05-23 | — | — | US | disclosed |
| EP-2694047-B1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | US HEALTH (US) | 2018-11-28 | — | — | EP | disclosed |
| US-20170367998-A1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES | 2017-12-28 | — | — | US | disclosed |
| US-20170362633-A1 | NRAS RELATED CANCER THERAPY | BRANDEIS UNIVERSITY | 2017-12-21 | — | — | US | disclosed |
| US-9629816-B2 | Small molecule therapeutic compounds targeting thioesterase deficiency disorders and methods of using the same | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2017-04-25 | — | — | US | disclosed |
| WO-2016090276-A1 | NRAS RELATED CANCER THERAPY | BRANDEIS UNIVERSITY (US) | 2016-06-09 | — | — | WO | disclosed |
| US-20140148513-A1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2014-05-29 | — | — | US | disclosed |
| EP-2694047-A1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20130101582-A1 | Tiki1 and Tiki2, Wnt Inhibitors | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2013-04-25 | — | — | US | disclosed |
| WO-2012139119-A1 | SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-10-11 | — | — | WO | disclosed |
| US-20110231942-A1 | TIKI1 AND TIKI2, WNT INHIBITORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-22 | — | — | US | disclosed |