Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | MC5R | P33032 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24191146 | 0.76 | LOXL2 (0.44) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL9357068 | 0.75 | HPGD (0.56) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL24796171 | 0.74 | CA12 (0.48) | ALDH1A1HSD17B10ALOX15TDP1LMNA | |
| SCHEMBL10927242 | 0.74 | ALDH1A1 (0.63) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL24795820 | 0.72 | HIF1A (0.36) | ALDH1A1CYP1A2HIF1ALMNACYP2D6 | |
| SCHEMBL28970350 | 0.72 | HIF1A (0.36) | ALDH1A1CYP1A2HIF1ALMNACYP2D6 | |
| SCHEMBL7628317 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL22292430 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL7633187 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL24795819 | 0.71 | RAB9A (0.57) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-06-29 | — | — | US | disclosed |
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-06-29 | — | — | US | disclosed |
| EP-4180090-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-05-17 | — | — | EP | disclosed |
| US-11535599-B2 | Benzisoxazole derivative | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11535599-B2 | Benzisoxazole derivative | HDAC3, GABRA5, HDAC2 | ALDH1A1 353/4885HPGD 1328/4885HSD17B10 700/4885 |
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | HDAC3, GABRA5, HDAC2 | ALDH1A1 353/4885HPGD 1328/4885HSD17B10 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.