Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533925 | 0.90 | LMNA (0.45) | LMNAPOLBSMN1; SMN2MMP3MMP9 | |
| SCHEMBL31454859 | 0.88 | ALDH1A1 (0.42) | LMNAPOLBALDH1A1KDM4EPKM | |
| SCHEMBL1895618 | 0.82 | LMNA (0.43) | LMNAPOLBSMN1; SMN2KDM4ECHRM2 | |
| SCHEMBL28926595 | 0.82 | CHRNB2 (0.39) | SMN1; SMN2ALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL31722736 | 0.82 | LMNA (0.47) | LMNAPOLBSMN1; SMN2MMP3MMP9 | |
| SCHEMBL29574427 | 0.81 | SMN1; SMN2 (0.42) | LMNAPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29598912 | 0.81 | LMNA (0.49) | LMNAPOLBSMN1; SMN2MMP3MMP9 | |
| SCHEMBL1445031 | 0.80 | LMNA (0.48) | LMNAPOLBSMN1; SMN2MMP3MMP9 | |
| SCHEMBL15166573 | 0.80 | LMNA (0.48) | LMNAPOLBSMN1; SMN2MMP3MMP9 | |
| SCHEMBL10097950 | 0.80 | LMNA (0.48) | LMNAPOLBSMN1; SMN2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |