Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 3/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30720821 | 1.00 | TERT (0.48) | TERTDHFRCDK5PDK1AURKA | |
| SCHEMBL29158066 | 0.91 | EGFR (0.47) | DHFREGFRALDH1A1KDM4ENPC1 | |
| SCHEMBL30720818 | 0.91 | EGFR (0.47) | DHFREGFRALDH1A1KDM4ENPC1 | |
| SCHEMBL24800587 | 0.89 | DHFR (0.43) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL29157692 | 0.86 | DHFR (0.46) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL29157760 | 0.86 | DHFR (0.41) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL30720819 | 0.86 | DHFR (0.46) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL24800573 | 0.85 | DHFR (0.41) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL30720823 | 0.85 | DHFR (0.41) | DHFRCDK5PDK1AURKAJAK2 | |
| SCHEMBL29157712 | 0.85 | DHFR (0.41) | DHFRCDK5PDK1AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597125-A | Indole-substituted quinolines and their use in combination with PLK1 inhibitors for the treatment of cancer | 肯塔基大学研究基金会 | 2024-02-23 | — | — | CN | disclosed |
| WO-2022271676-A1 | INDOLE-SUBSTITUTED QUINOLINES AND THEIR COMBINATION WITH PLK1 INHIBITORS FOR THE TREATMENT OF CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-12-29 | — | — | WO | disclosed |