Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CASP1 | P29466 | 4/20 | 0.46 |
| ▸ | CASP7 | P55210 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | HTR3A | P46098 | 5/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29158066 | 1.00 | EGFR (0.47) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL30720821 | 0.91 | TERT (0.48) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL24801583 | 0.91 | TERT (0.48) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL24800587 | 0.89 | DHFR (0.43) | EGFRMEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL30720819 | 0.86 | DHFR (0.46) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL29157692 | 0.86 | DHFR (0.46) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL29157760 | 0.86 | DHFR (0.41) | EGFRDHFR | |
| SCHEMBL24800573 | 0.85 | DHFR (0.41) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL29157712 | 0.85 | DHFR (0.41) | EGFRMEN1ALDH1A1CYP3A4CASP1 | |
| SCHEMBL30720823 | 0.85 | DHFR (0.41) | EGFRMEN1ALDH1A1CYP3A4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630532-B2 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2026-05-19 | — | — | US | disclosed |
| US-20240300921-A1 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | UNIV KENTUCKY RES FOUND (US) | 2024-09-12 | — | — | US | disclosed |
| CN-117597125-A | Indole-substituted quinolines and their use in combination with PLK1 inhibitors for the treatment of cancer | 肯塔基大学研究基金会 | 2024-02-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300921-A1 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | PLK1, MYC, PLK4 | EGFR 1961/4885MEN1 1343/4885ALDH1A1 3074/4885 |
| US-12630532-B2 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | PLK1, MYC, PLK4 | EGFR 1373/4885MEN1 1485/4885ALDH1A1 1529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.