Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 2/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29157692 | 1.00 | DHFR (0.46) | DHFRC1SIP6K1EGFRPRKCB | |
| SCHEMBL30720822 | 0.94 | DHFR (0.44) | DHFRC1SIP6K1EGFRPDK1 | |
| SCHEMBL24800578 | 0.94 | DHFR (0.44) | DHFRC1SIP6K1EGFRPDK1 | |
| SCHEMBL24800587 | 0.89 | DHFR (0.43) | DHFREGFRPRKCBPRKCAPRKCH | |
| SCHEMBL29157760 | 0.86 | DHFR (0.41) | DHFREGFRPDK1AURKAJAK2 | |
| SCHEMBL29157728 | 0.86 | DHFR (0.42) | DHFREGFRPRKCEMEN1USP2 | |
| SCHEMBL24801583 | 0.86 | TERT (0.48) | DHFRIP6K1EGFRPDK1AURKA | |
| SCHEMBL30720821 | 0.86 | TERT (0.48) | DHFRIP6K1EGFRPDK1AURKA | |
| SCHEMBL30720818 | 0.86 | EGFR (0.47) | DHFREGFRPRKCBPRKCAPRKCH | |
| SCHEMBL29158066 | 0.86 | EGFR (0.47) | DHFREGFRPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630532-B2 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2026-05-19 | — | — | US | disclosed |
| US-20240300921-A1 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | UNIV KENTUCKY RES FOUND (US) | 2024-09-12 | — | — | US | disclosed |
| CN-117597125-A | Indole-substituted quinolines and their use in combination with PLK1 inhibitors for the treatment of cancer | 肯塔基大学研究基金会 | 2024-02-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300921-A1 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | PLK1, MYC, PLK4 | DHFR 930/4885C1S 2892/4885IP6K1 314/4885 |
| US-12630532-B2 | Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer | PLK1, MYC, PLK4 | DHFR 1660/4885C1S 1325/4885IP6K1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.