SCHEMBL248077

SCHEMBL248077

Nc1ccc(C(=O)OC(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.59
CYP1A2 P05177 3/20 0.59
CYP3A4 P08684 3/20 0.59
MAOA P21397 2/20 0.59
TSHR P16473 2/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
PDE4D Q08499 1/20 0.52
PHLPP2 Q6ZVD8 1/20 0.50
PARP10 Q53GL7 1/20 0.50
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
MAPT P10636 2/20 0.48
ALDH1A1 P00352 1/20 0.48
F2 P00734 2/20 0.47
PRSS1 P07477 2/20 0.47
PRSS2 P07478 2/20 0.47
PRSS3 P35030 2/20 0.47
PKM P14618 2/20 0.47
KMT2A Q03164 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL248078 0.91 NPC1 (0.56) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL28446692 0.90 LMNA (0.55) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL2145960 0.88 LMNA (0.53) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL28659060 0.88 LMNA (0.53) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL28446693 0.88 LMNA (0.53) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL30790800 0.86 LMNA (0.52) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL5781148 0.85 LOXL2 (0.61) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL10475419 0.84 LMNA (0.50) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL6228872 0.84 LMNA (0.59) LMNACYP1A2CYP3A4MAOATSHR
SCHEMBL1417358 0.84 PBRM1 (0.52) LMNACYP1A2CYP3A4MAOATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115724815-A Dianhydride monomer containing amide structure and trifluoromethyl, polyimide film and preparation method thereof 安徽国风新材料股份有限公司 2023-03-03 CN claimed
CN-112521603-A Polyamide acid block copolymer and preparation method thereof, polyimide copper-clad plate and circuit board 臻鼎科技股份有限公司 2021-03-19 CN claimed
CN-112239539-A Polyamide acid composition, polyimide copper-clad plate and circuit board 臻鼎科技股份有限公司 2021-01-19 CN claimed
US-20180273819-A1 THERMAL ENERGY STORAGE PHASE AND TEMPERATURE STABILIZATION CHANGE MATERIALS COMPRISING TRIAMINES AND METHODS FOR MAKING AND USING THEM ENTROPY SOLUTIONS LLC (US) 2018-09-27 US claimed
WO-2016179028-A1 THERMAL ENERGY STORAGE PHASE AND TEMPERATURE STABILIZATION CHANGE MATERIALS AND METHODS FOR MAKING AND USING THEM ENTROPY SOLUTIONS, LLC. (US) 2016-11-10 WO claimed
WO-2025015175-A2 HEATING, VENTILATION, AND AIR CONDITIONING (HVAC) SYSTEMS AND METHODS FOR USING SAME STASIS ENERGY GROUP, LLC (US) 2025-01-16 WO disclosed
US-20240254082-A1 Substituted Isoindoline-1, 3-diketone PDE4 Inhibitor and Pharmaceutical Application Thereof SUZHOU INTRAGRAND PHARMA CO., LTD (CN) 2024-08-01 US disclosed
CN-118236408-A Novel method for antagonizing toxicity of metalloid As based on magnetotactic bacteria AMB-1 中国科学院合肥物质科学研究院 2024-06-25 CN disclosed
EP-4385976-A1 SUBSTITUTED ISOINDOLIN-1,3-DIONE PDE4 INHIBITOR AND PHARMACEUTICAL USE THEREOF Suzhou Intragrand Pharma Co., Ltd (CN) 2024-06-19 EP disclosed
EP-3431547-B1 AQUEOUS DISPERSION, COMPRISING A CURABLE POLYESTER, RESOLE PHENOLIC RESINS AND WATER EASTMAN CHEM CO (US) 2023-10-25 EP disclosed
CN-115873417-B Disazo benzimidazolone pigment containing isosorbide structure and preparation method thereof 江苏丽王科技股份有限公司 2023-10-17 CN disclosed
EP-3428231-B1 CURABLE POLYESTERS AND THERMOSETTING COMPOSITIONS CONTAINING RESOLE PHENOLIC RESINS EASTMAN CHEM CO (US) 2023-08-30 EP disclosed
WO-2004058241-A1 INHIBITION OF MELANOGENESIS AND MELANOMA METASTASIS WITH P-AMINOBENZOIC ACID (PABA) NEW YORK UNIVERSITY (US) 2004-07-15 WO disclosed
US-20020123609-A1 Dendrimeric support or carrier macromolecule THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-09-05 US disclosed
WO-2002026867-A2 DENDRIMERIC SUPPORT OR CARRIER MACROMOLECULE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2002-04-04 WO disclosed
CN-1074898-C Ionene polymers containing biologically-active anions BUCKMAN LAB INT INC (US) 2001-11-21 CN disclosed
CN-1162246-A Ionene polymers containing biologically-active anions BUCKMAN LABOR INC (US) 1997-10-15 CN disclosed
US-4008175-A Organic acid anhydride-peroxydicarbonate composition PPG INDUSTRIES, INC. (US) 1977-02-15 US disclosed
US-3985720-A Polymerization of ethylenically unsaturated monomer employing a catalyst system comprising dialkylpyrocarbonate, organic acid anhydride, alkaline reagent and H2 O2 PPG INDUSTRIES, INC. (US) 1976-10-12 US disclosed
US-3978032-A ALKALINE BUFFER, ANHYDRIDE, PERACID, ALKYL HALOFORMATE PPG INDUSTRIES, INC. (US) 1976-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240254082-A1 Substituted Isoindoline-1, 3-diketone PDE4 Inhibitor and Pharmaceutical Application Thereof PDE4A, PDE4B, PDE3B LMNA 2923/4885CYP1A2 142/4885CYP3A4 20/4885
US-20020123609-A1 Dendrimeric support or carrier macromolecule CD44, TSG101, BST2 LMNA 1708/4885CYP1A2 4651/4885CYP3A4 4680/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.