Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.35 |
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30049517 | 1.00 | ACHE (0.35) | ACHEBCHEGRIN1GRIN2AJAK2 | |
| SCHEMBL30095582 | 0.86 | JAK2 (0.35) | ACHEBCHEGRIN1GRIN2AJAK2 | |
| SCHEMBL24808712 | 0.86 | JAK2 (0.35) | ACHEBCHEGRIN1GRIN2AJAK2 | |
| SCHEMBL23601547 | 0.84 | HTR2A (0.37) | ACHEBCHEGRIN1GRIN2AJAK2 | |
| SCHEMBL24806334 | 0.73 | ACHE (0.31) | ACHE | |
| SCHEMBL23601370 | 0.73 | HTR6 (0.33) | JAK2HTR1AHTR2AHTR2C | |
| SCHEMBL24806337 | 0.72 | RET (0.32) | — | |
| SCHEMBL23576649 | 0.72 | MAPT (0.34) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL30979164 | 0.72 | MAPT (0.34) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL23601543 | 0.69 | ACHE (0.37) | ACHEJAK2GSK3BMAPK10RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271684-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |