Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.39 |
| ▸ | ARNT | P27540 | 4/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.37 |
| ▸ | CUL4A | Q13619 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2505209 | 0.83 | PGR (0.41) | ARNTEPAS1CUL4A | |
| SCHEMBL2485667 | 0.82 | TRPM8 (0.46) | XPO1CUL4AMAPTKDM4ENPC1 | |
| SCHEMBL421731 | 0.81 | MAPK14 (0.46) | XPO1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL2482567 | 0.81 | MAPK14 (0.38) | XPO1ARNTEPAS1CHRM3 | |
| SCHEMBL2509882 | 0.77 | S1PR1 (0.36) | XPO1ARNTEPAS1ALDH1A1KMT2A | |
| SCHEMBL2505963 | 0.76 | FNTA (0.41) | ARNTEPAS1CNR2CHRM3TRPM8 | |
| SCHEMBL2483769 | 0.72 | CUL4A (0.47) | CUL4AMAPTKDM4ENPC1RAB9A | |
| SCHEMBL2482216 | 0.72 | XPO1 (0.39) | XPO1CUL4AMAPTNPC1RAB9A | |
| SCHEMBL17530795 | 0.70 | XPO1 (0.41) | XPO1EPAS1CUL4AMAPTKDM4E | |
| SCHEMBL2510401 | 0.70 | PGR (0.40) | ARNTEPAS1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-B1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |