Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986546 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBHSD11B1NPC1RAB9A | |
| SCHEMBL24817130 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBHSD11B1NPC1RAB9A | |
| SCHEMBL29986910 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2POLBHSD11B1NPC1RAB9A | |
| SCHEMBL24815673 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2POLBHSD11B1NPC1RAB9A | |
| SCHEMBL24815800 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL29986727 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL24814454 | 0.85 | DPP9 (0.44) | DPP9ALDH1A1HSP90B1TRAP1ROCK2 | |
| SCHEMBL29987274 | 0.82 | NAMPT (0.46) | DPP9HSP90B1TRAP1ROCK2ROCK1 | |
| SCHEMBL24814393 | 0.82 | NAMPT (0.46) | DPP9HSP90B1TRAP1ROCK2ROCK1 | |
| SCHEMBL24816196 | 0.79 | TAS1R3 (0.50) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827629-B2 | CDGSH iron sulfur domain 2 activators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2023-11-28 | — | — | US | disclosed |
| US-11827629-B2 | CDGSH iron sulfur domain 2 activators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2023-11-28 | — | — | US | disclosed |
| US-20220411418-A1 | CDGSH IRON SULFUR DOMAIN 2 ACTIVATORS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-12-29 | — | — | US | disclosed |
| WO-2022251343-A2 | CDGSH IRON SULFUR DOMAIN 2 ACTIVATORS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411418-A1 | CDGSH IRON SULFUR DOMAIN 2 ACTIVATORS AND USE THEREOF | CISD2, CISD1, FECH | SMN1; SMN2 1176/4885POLB 4115/4885HSD11B1 1364/4885 |
| US-11827629-B2 | CDGSH iron sulfur domain 2 activators and use thereof | CISD2, CISD1, FECH | SMN1; SMN2 1176/4885POLB 4115/4885HSD11B1 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.