Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30273749 | 0.92 | MAPT (0.38) | GRM5SRD5A2PKMHPGDMCL1 | |
| SCHEMBL31397268 | 0.90 | SRD5A2 (0.39) | GRM5SRD5A2PKMMCL1BAK1 | |
| SCHEMBL31397430 | 0.87 | FFAR1 (0.41) | GRM5SRD5A2PKMPPARGNR1H2 | |
| SCHEMBL30274180 | 0.85 | PKM (0.41) | GRM5SRD5A2PKMMCL1BAK1 | |
| SCHEMBL31397093 | 0.85 | MCHR1 (0.36) | GRM5SRD5A2PKMKDM4EALDH1A1 | |
| SCHEMBL30273755 | 0.84 | HDAC6 (0.40) | GRM5SRD5A2PKMMCL1BAK1 | |
| SCHEMBL30026709 | 0.84 | DGAT1 (0.40) | GRM5PKMPPARGPPARDPPARA | |
| SCHEMBL23540929 | 0.84 | DGAT1 (0.40) | GRM5PKMPPARGPPARDPPARA | |
| SCHEMBL24819487 | 0.84 | RXRA (0.39) | GRM5PKMMCL1BAK1PPARD | |
| SCHEMBL31397211 | 0.83 | DGAT1 (0.39) | GRM5SRD5A2PKMALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023019166-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | CALICO LIFE SCIENCES LLC (US) | 2023-02-16 | — | — | WO | disclosed |
| WO-2022271727-A1 | DEGRADER COMPOUNDS AND USES THEREOF | CALICO LIFE SCIENCES LLC (US) | 2022-12-29 | — | — | WO | disclosed |