Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30153052 | 1.00 | HDAC6 (0.42) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL24818763 | 0.89 | MAPT (0.38) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL30152867 | 0.89 | MAPT (0.38) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL30153034 | 0.89 | CYP11B2 (0.33) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL24821968 | 0.89 | CYP11B2 (0.33) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL30792132 | 0.89 | MAPT (0.38) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL24818715 | 0.87 | MAPT (0.45) | HDAC6MAPTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL30153198 | 0.86 | CETP (0.33) | — | |
| SCHEMBL24820485 | 0.86 | CETP (0.33) | — | |
| SCHEMBL24819948 | 0.84 | S1PR1 (0.35) | HDAC6HDAC3HDAC8HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |