Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24818914 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACLK1 | |
| SCHEMBL24818726 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACBLB | |
| SCHEMBL30152816 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACBLB | |
| SCHEMBL30153040 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACLK1 | |
| SCHEMBL30792096 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACLK1 | |
| SCHEMBL24818673 | 0.91 | HPGD (0.37) | HPGDCETPLMNAGAACLK1 | |
| SCHEMBL24820642 | 0.87 | HTR3A (0.35) | HPGDHDAC6 | |
| SCHEMBL24819725 | 0.87 | HPGD (0.34) | HPGDCETPLMNAGAACLK1 | |
| SCHEMBL24818951 | 0.86 | ESR2 (0.34) | HPGDCETPCBLBVSIR | |
| SCHEMBL30153245 | 0.86 | ESR2 (0.34) | HPGDCETPCBLBVSIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |