⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555498 | 1.00 | — | — | |
| SCHEMBL4557221 | 0.91 | CXCR4 (0.33) | — | |
| SCHEMBL414445 | 0.78 | — | — | |
| SCHEMBL24380 | 0.77 | — | — | |
| Ammonia Solution, Strong SCHEMBL28779669 | 0.74 | — | — | |
| Piperazine SCHEMBL28114722 | 0.74 | HIF1A (0.35) | — | |
| Hydrochloric Acid SCHEMBL7468053 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL18945716 | 0.74 | SIGMAR1 (0.30) | — | |
| SCHEMBL248268 | 0.73 | — | — | |
| SCHEMBL4557090 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217764-A1 | NOX INHIBITORS FOR USE IN THE TREATMENT OF ALPORT SYNDROME | CALLIDITAS THERAPEUTICS SUISSE SA (CH) | 2023-11-16 | — | — | WO | claimed |
| US-20210177811-A1 | USE OF NOX INHIBITORS FOR TREATMENT OF CANCER | CALLIDITAS THERAPEUTICS SUISSE SA (CH) | 2021-06-17 | — | — | US | claimed |
| EP-3703747-A1 | USE OF NOX INHIBITORS FOR TREATMENT OF CANCER | GenKyoTex Suisse SA (CH) | 2020-09-09 | — | — | EP | claimed |
| EP-3479843-A1 | USE OF NOX INHIBITORS FOR TREATMENT OF CANCER | GenKyoTex Suisse SA (CH) | 2019-05-08 | — | — | EP | claimed |
| CN-105801584-B | Novel aryl amide Raf kinase and its preparation method and application | 中国药科大学 | 2019-03-05 | — | — | CN | claimed |
| US-9603829-B2 | HSP90 inhibitors with modified toxicity | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-03-28 | — | — | US | claimed |
| CN-105801584-A | Novel aromatic amide Raf kinase inhibitors and preparation method and application thereof | 中国药科大学 | 2016-07-27 | — | — | CN | claimed |
| CN-105061422-A | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX S A | 2015-11-18 | — | — | CN | claimed |
| EP-2190291-B1 | HSP90 INHIBITORS WITH MODIFIED TOXICITY | UNIV COLORADO REGENTS (US) | 2015-10-14 | — | — | EP | claimed |
| US-9073919-B2 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-07-07 | — | — | US | claimed |
| CN-1359375-A | Novel piperazinylalkyl thiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of same | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2002-07-17 | — | — | CN | claimed |
| WO-2002053162-A1 | METHOD FOR TREATING GLAUCOMA IIIB | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | claimed |
| CN-1334798-A | Phenylglycine derivatives | HOFFMANN LA ROCHE (CH) | 2002-02-06 | — | — | CN | claimed |
| US-6207665-B1 | TO TREAT INFLAMMATORY DISORDERS IN HUMANS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-03-27 | — | — | US | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0544819-B1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1995-12-06 | — | — | EP | claimed |
| EP-0544819-A4 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | — | 1993-10-20 | — | — | EP | claimed |
| EP-0544819-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003132-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | claimed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | claimed |