Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 14/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3215 | 0.93 | AGTR1 (0.46) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL3362 | 0.92 | AGTR1 (0.47) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL3319 | 0.92 | AGTR1 (0.48) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL2796 | 0.91 | ALDH1A1 (0.54) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL2795 | 0.91 | ALDH1A1 (0.54) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL14193717 | 0.89 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2691 | 0.89 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2950 | 0.89 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL3473870 | 0.89 | AGTR1 (0.50) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL3473866 | 0.89 | AGTR1 (0.50) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |