Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.38 |
| ▸ | MYLK | Q15746 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24820600 | 0.86 | EIF4E (0.48) | KEAP1 | |
| SCHEMBL30792061 | 0.86 | EIF4E (0.48) | KEAP1 | |
| SCHEMBL30792152 | 0.81 | KDM4E (0.49) | CASP1ROCK1 | |
| SCHEMBL24820591 | 0.81 | KDM4E (0.49) | CASP1ROCK1 | |
| SCHEMBL5616629 | 0.80 | IKBKB (0.51) | GRM2SCN9AIKBKBCHUKGSK3A | |
| SCHEMBL4615110 | 0.78 | EIF4E (0.47) | GRM2SCN9ACASP1 | |
| SCHEMBL29189961 | 0.77 | TSHR (0.52) | CASP1 | |
| SCHEMBL5616503 | 0.77 | CASP1 (0.58) | GRM2CASP1 | |
| SCHEMBL4026875 | 0.77 | BCAT2 (0.61) | GRM2CASP1IKBKBCHUKKEAP1 | |
| SCHEMBL30463456 | 0.77 | BCAT2 (0.61) | GRM2CASP1IKBKBCHUKKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |