Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 8/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30792061 | 1.00 | EIF4E (0.48) | EIF4EKEAP1DHODHNFE2L2TTR | |
| SCHEMBL31319312 | 0.86 | POLB (0.43) | EIF4EKEAP1DHODHNFE2L2TTR | |
| SCHEMBL24820593 | 0.86 | GRM2 (0.45) | KEAP1 | |
| SCHEMBL30792148 | 0.85 | ALDH1A1 (0.53) | EIF4EDHODHALDH1A1HSD17B10KDM4E | |
| SCHEMBL24820734 | 0.85 | ALDH1A1 (0.53) | EIF4EDHODHALDH1A1HSD17B10KDM4E | |
| SCHEMBL24820591 | 0.82 | KDM4E (0.49) | ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL30792152 | 0.82 | KDM4E (0.49) | ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL6488777 | 0.80 | ANO1 (0.52) | EIF4EKEAP1DHODHTTRALDH1A1 | |
| SCHEMBL6498591 | 0.79 | HSD17B10 (0.58) | EIF4EKEAP1DHODHTTRALDH1A1 | |
| SCHEMBL31586500 | 0.79 | HSD17B10 (0.58) | EIF4EKEAP1DHODHTTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4637749-A2 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024137674-A2 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024086730-A1 | HETEROCYCLIC CBL-B INHIBITORS FOR THE TREATMENT OF CANCER | HOTSPOT THERAPEUTICS, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |