Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015772 | 0.91 | CA9 (0.47) | CA9ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7399575 | 0.82 | ITGB3 (0.57) | CA9ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7399576 | 0.82 | ITGB3 (0.57) | CA9ITGB3ITGA2BKDM4EMEN1 | |
| Methane SCHEMBL28580610 | 0.77 | CA9 (0.44) | CA9ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL2484227 | 0.75 | CMA1 (0.39) | — | |
| SCHEMBL4967797 | 0.72 | CA9 (0.34) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL15263464 | 0.72 | CA9 (0.41) | CA9ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL27771607 | 0.71 | CA9 (0.47) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL4017459 | 0.69 | PNMT (0.42) | GRIN2B | |
| SCHEMBL12450086 | 0.68 | PNMT (0.35) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |