Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482274 | 0.91 | CA9 (0.45) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL2484227 | 0.83 | CMA1 (0.39) | MTNR1A | |
| SCHEMBL4017459 | 0.77 | PNMT (0.42) | GRIN2B | |
| SCHEMBL15263464 | 0.77 | CA9 (0.41) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL27771607 | 0.76 | CA9 (0.47) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL12450086 | 0.76 | PNMT (0.35) | MTNR1ABRD4 | |
| SCHEMBL7140193 | 0.75 | MTNR1A (0.34) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL4967797 | 0.74 | CA9 (0.34) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL7399575 | 0.72 | ITGB3 (0.57) | CA9KDM4EMEN1GAAMAPT | |
| SCHEMBL7399576 | 0.72 | ITGB3 (0.57) | CA9KDM4EMEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |