Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187172 | 0.84 | BRD4 (0.60) | BRD4ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL29922777 | 0.84 | BRD4 (0.60) | BRD4ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL457581 | 0.84 | MAPT (0.54) | BRD4ALDH1A1HSD17B10MAPTCYP1A2 | |
| SCHEMBL21940230 | 0.82 | L3MBTL1 (0.45) | ALDH1A1HSD17B10MAPTCYP1A2CYP3A4 | |
| SCHEMBL13460683 | 0.78 | NAPRT (0.53) | ALDH1A1HSD17B10MAPTCYP1A2CYP3A4 | |
| SCHEMBL2482284 | 0.75 | BRD4 (0.43) | BRD4ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL1408357 | 0.74 | MAPT (0.53) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4244032 | 0.74 | BRD4 (0.55) | BRD4ALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL27611622 | 0.73 | ALDH1A1 (0.60) | BRD4ALDH1A1HSD17B10MAPTCYP1A2 | |
| SCHEMBL5479636 | 0.72 | CES2 (0.60) | ALDH1A1HSD17B10MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3655398-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | Phenex-FXR GmbH (DE) | 2020-05-27 | — | — | EP | disclosed |
| US-20200131144-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-30 | — | — | US | disclosed |
| CN-110914248-A | LXR modulators containing amines or (thio) amides | 菲尼克斯-FXR股份有限公司 | 2020-03-24 | — | — | CN | disclosed |
| WO-2019016269-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2019-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131144-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | NR1H2, NR1H3, NR1H4 | BRD4 551/4885ALDH1A1 2016/4885HSD17B10 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.