Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767456 | 0.86 | ALDH1A1 (0.48) | FFAR1MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL13349164 | 0.79 | MTNR1A (0.42) | FFAR1MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL103718 | 0.78 | KEAP1 (0.39) | CSF1RFFAR1MTNR1AMTNR1BNPC1 | |
| SCHEMBL5746155 | 0.77 | MTNR1A (0.39) | FFAR1MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL3271862 | 0.76 | MTNR1A (0.39) | FFAR1MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL9366721 | 0.74 | NPC1 (0.47) | CSF1RNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL21037538 | 0.73 | NPC1 (0.48) | CSF1RNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL21847982 | 0.73 | FFAR1 (0.57) | FFAR1MTNR1A | |
| SCHEMBL15318884 | 0.72 | MAOB (0.54) | CSF1RNPC1RAB9AMAOBNTRK1 | |
| SCHEMBL9686722 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376497-B1 | 5-AMINO-2-(1-HYDROXY-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-8211890-B2 | 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives | Actelion Pharmaceuticals (CH) | 2012-07-03 | — | — | US | disclosed |
| EP-2376497-A1 | 5-AMINO-2-(1-HYDROXY-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2011-10-19 | — | — | EP | disclosed |
| US-20110245259-A1 | 5-Amino-2-(1-Hydroxy-Ethyl)-Tetrahydropyran Derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-10-06 | — | — | US | disclosed |
| WO-2010067332-A1 | 5-AMINO-2-(1-HYDROXY-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245259-A1 | 5-Amino-2-(1-Hydroxy-Ethyl)-Tetrahydropyran Derivatives | CD2, CD22, DRD3 | CSF1R 939/4885FFAR1 1296/4885MTNR1A 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.