Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 10/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20283120 | 0.73 | CHRM4 (0.48) | CHRM4GRM4 | |
| Hydrochloric Acid SCHEMBL21797156 | 0.72 | CHRM4 (0.48) | CHRM4GRM4 | |
| SCHEMBL633108 | 0.65 | PIM2 (0.31) | PIM2 | |
| SCHEMBL5183086 | 0.63 | ALDH1A1 (0.42) | NNMT | |
| SCHEMBL9398884 | 0.62 | LOX (0.44) | BCHE | |
| SCHEMBL16685020 | 0.62 | CHRM4 (0.47) | CHRM4 | |
| SCHEMBL3334998 | 0.61 | CCR2 (0.49) | — | |
| Hydrochloric Acid SCHEMBL17077952 | 0.61 | CHRM4 (0.47) | CHRM4 | |
| SCHEMBL3720300 | 0.60 | FFAR4 (0.32) | FFAR4 | |
| SCHEMBL23232311 | 0.60 | LOX (0.45) | BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376475-A1 | 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANOL ANTAGONISTS OF CCR2 | Janssen Pharmaceutica N.V. (BE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010068663-A1 | 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANOL ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-06-17 | — | — | WO | disclosed |