Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 10/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16385656 | 0.84 | HTR1D (0.49) | FASNALDH1A1 | |
| SCHEMBL13478358 | 0.83 | ALDH1A1 (0.51) | FASNALDH1A1RAB9A | |
| SCHEMBL520958 | 0.81 | DRD4 (0.47) | RAD52DRD4ALDH1A1DRD2DRD3 | |
| SCHEMBL521024 | 0.78 | DRD4 (0.49) | RAD52GFERDRD4ALDH1A1DRD2 | |
| SCHEMBL519477 | 0.72 | SLC18A3 (0.48) | DRD4DRD2DRD3JAK2PTK2 | |
| SCHEMBL3436234 | 0.71 | CCNT1 (0.44) | DRD4ALDH1A1DRD2 | |
| SCHEMBL13723827 | 0.71 | DRD4 (0.53) | RAD52GFERDRD4ALDH1A1DRD2 | |
| SCHEMBL27860633 | 0.70 | DRD4 (0.44) | RAD52GFERDRD4ALDH1A1DRD2 | |
| SCHEMBL3436615 | 0.70 | OPRL1 (0.50) | DRD4ALDH1A1RAB9A | |
| SCHEMBL13569780 | 0.70 | GABRP (0.41) | DRD4DRD2DRD3JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |