Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | OGT | O15294 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910847 | 0.81 | PSMB8 (0.53) | PARP1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL6802027 | 0.80 | PARP1 (0.58) | PARP1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL21048201 | 0.75 | ALDH1A1 (0.46) | EPHX2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL9954720 | 0.73 | GPR35 (0.40) | EPHX2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL2149156 | 0.72 | OGT (0.43) | PARP1MAPTGAAOGTTDP1 | |
| SCHEMBL5540274 | 0.71 | MCL1 (0.49) | EPHX2MCL1OGTNOS1GRM5 | |
| SCHEMBL2484702 | 0.71 | MCL1 (0.49) | EPHX2PARP1MCL1OGTTDP1 | |
| SCHEMBL3043379 | 0.71 | MCL1 (0.49) | EPHX2MCL1OGTGRM5 | |
| SCHEMBL1285749 | 0.71 | EPHX2 (0.50) | EPHX2MCL1OGTNOS3NOS1 | |
| SCHEMBL5077255 | 0.71 | PSMB8 (0.61) | EPHX2MCL1OGTCYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156712-A | It is a kind of to utilize aromatic nitration by-product synthesis benzoxazoles class compound and application | 邵玉田 | 2019-08-23 | — | — | CN | disclosed |
| US-10233177-B2 | TRPV1 vanilloid receptor antagonists with a bicyclic portion | SERENTRIX, LLC | 2019-03-19 | — | — | US | disclosed |
| EP-2552888-B1 | TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION | SERENTRIX LLC (US) | 2018-09-26 | — | — | EP | disclosed |
| US-20170152252-A1 | TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion | SERENTRIX, LLC | 2017-06-01 | — | — | US | disclosed |
| US-20160289199-A1 | TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion | SERENTRIX LLC (US) | 2016-10-06 | — | — | US | disclosed |
| US-9216975-B2 | TRPV1 vanilloid receptor antagonists with a bicyclic portion | Serentrix, LLC. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20130079339-A1 | TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION | PHARMESTE S.R.L. (IT) | 2013-03-28 | — | — | US | disclosed |
| EP-2552888-A1 | \"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION\ | Pharmeste S.r.l. (IT) | 2013-02-06 | — | — | EP | disclosed |
| EP-2377850-A1 | TRPV1 vanilloid receptor antagonists with a bicyclic portion | Pharmeste S.r.l. (IT) | 2011-10-19 | — | — | EP | disclosed |
| EP-2377850-A1 | TRPV1 vanilloid receptor antagonists with a bicyclic portion | Pharmeste S.r.l. (IT) | 2011-10-19 | — | — | EP | disclosed |
| WO-2011120604-A1 | \"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION\ | PHARMESTE S.R.L. (IT) | 2011-10-06 | — | — | WO | disclosed |
| US-7816376-B2 | Cyclic amides | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| EP-1485363-B1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2008-10-08 | — | — | EP | disclosed |
| US-20050124627-A1 | Cyclic amides | MERCK PATENT GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| EP-1485363-A1 | CYCLIC AMIDES | MERCK PATENT GmbH (DE) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003076420-A1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2003-09-18 | — | — | WO | disclosed |
| EP-0406993-A2 | Substituted benzoxazolinone and benzoxazinone derivatives, process for their preparation and their use as agent with herbicide activity | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-01-09 | — | — | EP | disclosed |
| US-4668610-A | 2-equivalent cyan dye-forming 5-hydroxy-6-acylamino-benzoxazole-2-one couplers, silver halide photographic elements and processes employing them | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0193051-A2 | 2-Equivalent cyan dye-forming 5-hydroxy-6-acylamino-benzoxazole-2-one couplers, silver halide photographic elements and processes employing them | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1986-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152252-A1 | TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion | TRPV1, TRPV5, TRPV3 | EPHX2 964/4885PARP1 2505/4885MAPT 3327/4885 |
| US-20050124627-A1 | Cyclic amides | NPY1R, GRIK1, GRIK4 | EPHX2 917/4885PARP1 2584/4885MAPT 451/4885 |
| US-10233177-B2 | TRPV1 vanilloid receptor antagonists with a bicyclic portion | TRPV1, TRPV5, TRPV3 | EPHX2 964/4885PARP1 2505/4885MAPT 3327/4885 |
| US-20160289199-A1 | TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion | TRPV1, TRPV5, TRPV3 | EPHX2 964/4885PARP1 2505/4885MAPT 3327/4885 |
| US-20130079339-A1 | TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION | TRPV1, TRPV5, TRPV3 | EPHX2 964/4885PARP1 2505/4885MAPT 3327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.