Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24826137 | 0.87 | RECQL (0.43) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL29206652 | 0.87 | RECQL (0.43) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL29206650 | 0.87 | RECQL (0.43) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL24826699 | 0.87 | RECQL (0.43) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL29124147 | 0.82 | ALDH1A1 (0.38) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL29124148 | 0.82 | ALDH1A1 (0.38) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL5109520 | 0.82 | GPR119 (0.48) | RECQLHPGDGPR119USP2SMN1; SMN2 | |
| SCHEMBL24197695 | 0.79 | NR1H2 (0.43) | RECQLHPGDGPR119ALDH1A1MEN1 | |
| SCHEMBL850416 | 0.79 | GPR119 (0.46) | RECQLHPGDGPR119USP2SMN1; SMN2 | |
| SCHEMBL29124139 | 0.77 | MAPT (0.39) | RECQLHPGDGPR119ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271612-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022271612-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |