Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A1 | P54219 | 1/20 | 0.67 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | GRB2 | P62993 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19398068 | 0.88 | LCK (0.66) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL14527910 | 0.88 | SLC18A1 (0.65) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL13589339 | 0.87 | CA12 (0.64) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL12948892 | 0.81 | SLC18A1 (0.57) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL29360977 | 0.81 | SLC18A1 (1.00) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL14669803 | 0.80 | SLC18A1 (0.70) | SLC18A1SLC18A2KDM4EALDH1A1GLA | |
| SCHEMBL180110 | 0.80 | LCK (0.55) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL31415321 | 0.80 | LCK (0.55) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL723839 | 0.80 | LCK (0.76) | KDM4EALDH1A1GLAGAACA12 | |
| SCHEMBL13589337 | 0.80 | KDM4E (0.55) | SLC18A1SLC18A2KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024146906-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2024-07-11 | — | — | WO | disclosed |
| EP-4397674-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023275357-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2023-01-05 | — | — | WO | disclosed |
| EP-4112631-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2023-01-04 | — | — | EP | disclosed |