Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 17/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24834529 | 0.94 | NLRP3 (0.52) | NLRP3 | |
| SCHEMBL24834599 | 0.87 | NLRP3 (0.42) | NLRP3P2RX3 | |
| SCHEMBL24835107 | 0.85 | NLRP3 (0.67) | NLRP3 | |
| SCHEMBL30168573 | 0.84 | NLRP3 (0.60) | NLRP3GPR139 | |
| SCHEMBL24077213 | 0.84 | NLRP3 (0.60) | NLRP3GPR139 | |
| SCHEMBL24077345 | 0.83 | NLRP3 (0.52) | NLRP3 | |
| SCHEMBL24076982 | 0.82 | NLRP3 (0.55) | NLRP3 | |
| SCHEMBL24077227 | 0.82 | NLRP3 (0.55) | NLRP3 | |
| SCHEMBL24834601 | 0.81 | NLRP3 (0.41) | NLRP3P2RX3 | |
| SCHEMBL29660868 | 0.80 | NLRP3 (0.57) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |