Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447558 | 0.88 | HDAC8 (0.56) | HDAC8 | |
| Trifluoroacetic Acid SCHEMBL17542042 | 0.71 | SLC6A2 (0.53) | KDM1ACES1 | |
| SCHEMBL21180314 | 0.71 | TAAR1 (0.38) | HDAC8 | |
| SCHEMBL11806073 | 0.68 | KDM4E (0.47) | HDAC8CES1RAB9A | |
| Trifluoroacetic Acid SCHEMBL22123632 | 0.65 | KDM1A (0.42) | KDM1AOPRM1OPRD1RAB9A | |
| Trifluoroacetic Acid SCHEMBL20262609 | 0.65 | FFAR1 (0.59) | HDAC8CPA1CES1 | |
| SCHEMBL6965046 | 0.64 | NOS1 (0.44) | HDAC8 | |
| Ethylbenzene SCHEMBL8525583 | 0.63 | TP53 (0.61) | CPA1CES1RAB9A | |
| Benzylamine SCHEMBL5450068 | 0.63 | LOXL2 (0.61) | CPA1CES1 | |
| Phenylacetic Acid SCHEMBL27489228 | 0.63 | AKR1B1 (0.74) | CPA1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467381-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2012-06-27 | — | — | EP | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2011020822-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2011-02-24 | — | — | WO | disclosed |
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |