Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482216 | 0.83 | XPO1 (0.39) | CHRM3CTSA | |
| SCHEMBL2483630 | 0.80 | KMO (0.39) | — | |
| SCHEMBL418255 | 0.79 | MCL1 (0.43) | EGLN1AKR1C3AKR1C2APPAKR1C1 | |
| SCHEMBL2486902 | 0.78 | RPA1 (0.41) | AKR1C3AKR1C2APPAKR1C1CHRM3 | |
| SCHEMBL419322 | 0.72 | XPO1 (0.43) | CHRM3 | |
| SCHEMBL2486195 | 0.67 | CHRNA4 (0.32) | — | |
| SCHEMBL2485562 | 0.67 | MAPK14 (0.38) | CHRM3 | |
| SCHEMBL5230844 | 0.65 | GPR35 (0.39) | — | |
| SCHEMBL420353 | 0.65 | CHRNA4 (0.33) | — | |
| SCHEMBL2486656 | 0.65 | PGR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376479-B1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-2376479-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075957-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |