Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484122 | 0.85 | XPO1 (0.36) | RPA1APPCHRM3PGRTSPO | |
| SCHEMBL417818 | 0.82 | RPA1 (0.53) | RPA1KMOAPPAKR1C3AKR1C2 | |
| SCHEMBL2484720 | 0.78 | EGLN1 (0.32) | APPAKR1C3AKR1C2CHRM3AKR1C1 | |
| SCHEMBL2485562 | 0.76 | MAPK14 (0.38) | KMOCHRM2CHRM1CHRM3 | |
| SCHEMBL2480833 | 0.75 | RXRA (0.41) | KMOPTGS2 | |
| SCHEMBL2509896 | 0.75 | PGR (0.42) | RPA1CHRM2CHRM1CHRM3PGR | |
| SCHEMBL2481398 | 0.74 | PTGS2 (0.36) | RPA1KMOAPPCHRM2CHRM1 | |
| SCHEMBL415891 | 0.72 | RAB9A (0.44) | — | |
| SCHEMBL416571 | 0.70 | DPP4 (0.38) | RPA1 | |
| SCHEMBL416781 | 0.69 | RPA1 (0.34) | RPA1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376479-B1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-2376479-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075957-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |