Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | IL4I1 | Q96RQ9 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24851999 | 0.86 | GUSB (0.56) | GUSBIL4I1EGFRERBB2KDM4E | |
| SCHEMBL24851962 | 0.85 | IL4I1 (0.51) | IL4I1EGFRERBB2KDM4EALDH1A1 | |
| SCHEMBL24852507 | 0.82 | IL4I1 (0.51) | IL4I1EGFRKDM4EALDH1A1HPGD | |
| SCHEMBL24851920 | 0.81 | IL4I1 (0.47) | IL4I1EGFRERBB2KDM4EALDH1A1 | |
| SCHEMBL24852501 | 0.81 | IL4I1 (0.56) | IL4I1EGFRERBB2KDM4EALDH1A1 | |
| SCHEMBL24852000 | 0.80 | EGFR (0.55) | GUSBIL4I1EGFRERBB2ALDH1A1 | |
| SCHEMBL24851911 | 0.80 | IL4I1 (0.46) | GUSBIL4I1EGFRERBB2KDM4E | |
| SCHEMBL24851914 | 0.78 | IDO1 (0.48) | GUSBIL4I1EGFRKDM4EALDH1A1 | |
| SCHEMBL24852502 | 0.78 | KDM4E (0.45) | IL4I1EGFRKDM4EALDH1A1HPGD | |
| SCHEMBL24851925 | 0.76 | IL4I1 (0.46) | IL4I1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |