Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987368 | 0.79 | MAOA (0.37) | MAOAMAOBLMNAHTTKDM1A | |
| SCHEMBL6984753 | 0.78 | ELANE (0.33) | MAOAMAOBELANE | |
| SCHEMBL1968441 | 0.72 | BACE1 (0.43) | BACE1MAOAMAOBELANEHTT | |
| SCHEMBL6985348 | 0.71 | SIGMAR1 (0.38) | MAOAOPRM1OPRK1OPRL1 | |
| SCHEMBL10535790 | 0.70 | — | — | |
| SCHEMBL2486825 | 0.70 | BACE1 (0.38) | BACE1MAOAMAOBLMNATSHR | |
| SCHEMBL11058571 | 0.69 | MAOA (0.37) | MAOAMAOBELANELMNAHTT | |
| SCHEMBL5028984 | 0.69 | MAOA (0.43) | MAOAMAOBELANEOPRM1OPRK1 | |
| SCHEMBL11874420 | 0.69 | — | — | |
| SCHEMBL3620624 | 0.67 | TAAR1 (0.55) | BACE1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379521-A1 | SULFAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080397-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |