Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987368 | 0.90 | MAOA (0.37) | MAOAMAOB | |
| SCHEMBL6985348 | 0.81 | SIGMAR1 (0.38) | MAOA | |
| SCHEMBL2485448 | 0.78 | BACE1 (0.38) | ELANEMAOAMAOB | |
| SCHEMBL4985790 | 0.69 | SIGMAR1 (0.43) | ELANE | |
| SCHEMBL29228003 | 0.69 | MAOA (0.42) | ELANEMAOAMAOBTP53 | |
| SCHEMBL6003266 | 0.66 | MAOA (0.44) | MAOAMAOB | |
| SCHEMBL4720537 | 0.66 | HTR1A (0.36) | — | |
| SCHEMBL6988218 | 0.65 | ADRA2A (0.32) | ELANEMAOAMAOB | |
| SCHEMBL4724737 | 0.64 | HTR1A (0.38) | — | |
| SCHEMBL22444592 | 0.64 | LMNA (0.44) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |