Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.37 |
| ▸ | MAOB | P27338 | 7/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984753 | 0.90 | ELANE (0.33) | MAOAMAOB | |
| SCHEMBL6985348 | 0.86 | SIGMAR1 (0.38) | MAOAPOLBSIGMAR1 | |
| SCHEMBL2485448 | 0.79 | BACE1 (0.38) | MAOAMAOBKDM1ALMNAHTT | |
| SCHEMBL6003266 | 0.70 | MAOA (0.44) | MAOAMAOBKDM1ASIGMAR1HTT | |
| SCHEMBL28293435 | 0.68 | MAOA (0.45) | MAOAMAOBKDM1APOLBLMNA | |
| SCHEMBL180960 | 0.67 | MAOA (0.39) | MAOAMAOBKDM1APOLBSIGMAR1 | |
| SCHEMBL1007966 | 0.66 | MAOA (0.38) | MAOAMAOBKDM1APOLBSIGMAR1 | |
| SCHEMBL2582409 | 0.66 | MAOA (0.38) | MAOAMAOBKDM1APOLBSIGMAR1 | |
| SCHEMBL1009359 | 0.66 | MAOA (0.38) | MAOAMAOBKDM1APOLBSIGMAR1 | |
| SCHEMBL1009707 | 0.66 | MAOA (0.38) | MAOAMAOBKDM1APOLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |