Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.83 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.79 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | KDM1A | O60341 | 1/20 | 0.71 |
| ▸ | XDH | P47989 | 1/20 | 0.71 |
| ▸ | IPMK | Q8NFU5 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.68 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321016 | 0.91 | CYP1B1 (0.86) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL30410973 | 0.91 | CYP1B1 (0.86) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL2483636 | 0.91 | CYP1B1 (1.00) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL30365934 | 0.91 | CYP1B1 (1.00) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL29883103 | 0.91 | CYP1B1 (1.00) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL2874033 | 0.89 | POLH (0.79) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL2322974 | 0.88 | POLH (1.00) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL30255788 | 0.88 | POLH (1.00) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL4279323 | 0.87 | ABCB1 (0.80) | CYP1B1POLHCYP1A1CYP1A2MEN1 | |
| SCHEMBL5135091 | 0.86 | MAOA (0.82) | CYP1B1POLHCYP1A1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669003-B2 | Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs | JIN YONGRI (CN) | 2017-06-06 | — | — | US | claimed |
| US-20150196529-A1 | USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS | JIN YONGRI (CN) | 2015-07-16 | — | — | US | claimed |
| US-9669003-B2 | Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs | JIN YONGRI (CN) | 2017-06-06 | — | — | US | disclosed |
| CN-105497005-A | Application of flavonoid compound in treatment of inflammatory diseases | INST BOTANY JIANGSU PROVINCE & CAS | 2016-04-20 | — | — | CN | disclosed |
| US-20150196529-A1 | USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS | JIN YONGRI (CN) | 2015-07-16 | — | — | US | disclosed |
| CN-101601760-B | Application of murraya jasminorage leaf total flavonoids in preparing medicaments for treating diabetes | CHANGCHUN RUIDE MEDICINE TECHNOLOGY CO LTD | 2013-08-14 | — | — | CN | disclosed |
| US-8203011-B2 | 3′,4′,5-trimethoxy flavone derivatives as stimulant of mucus secretion, method for the same, and pharmaceutical composition comprising the same | DONG-A PHARM. CO., LTD. (KR) | 2012-06-19 | — | — | US | disclosed |
| US-8203011-B2 | 3′,4′,5-trimethoxy flavone derivatives as stimulant of mucus secretion, method for the same, and pharmaceutical composition comprising the same | DONG-A PHARM. CO., LTD. (KR) | 2012-06-19 | — | — | US | disclosed |
| US-8203011-B2 | 3′,4′,5-trimethoxy flavone derivatives as stimulant of mucus secretion, method for the same, and pharmaceutical composition comprising the same | DONG-A PHARM. CO., LTD. (KR) | 2012-06-19 | — | — | US | disclosed |
| EP-2170857-B1 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULANT OF MUCUS SECRETION, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG A PHARM CO LTD (KR) | 2011-10-19 | — | — | EP | disclosed |
| US-20100130448-A1 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULATN OF MUCUS SECRETION, METHOD FOR THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG-A PHARM. CO., LTD (KR) | 2010-05-27 | — | — | US | disclosed |
| US-20100130448-A1 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULATN OF MUCUS SECRETION, METHOD FOR THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG-A PHARM. CO., LTD (KR) | 2010-05-27 | — | — | US | disclosed |
| US-20100130448-A1 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULATN OF MUCUS SECRETION, METHOD FOR THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG-A PHARM. CO., LTD (KR) | 2010-05-27 | — | — | US | disclosed |
| EP-2170857-A2 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULANT OF MUCUS SECRETION, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Dong-A Pharm.Co., Ltd. (KR) | 2010-04-07 | — | — | EP | disclosed |
| CN-101380379-A | Total flavone in leaves of Murraya paniculata (L.) Jack and preparation method and use thereof | YONGRI JIN (CN) | 2009-03-11 | — | — | CN | disclosed |
| WO-2008150085-A2 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULANT OF MUCUS SECRETION, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG-A PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | disclosed |
| US-7371775-B2 | 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone monohydrate, the preparation method and uses thereof | DONG-A PHARMACEUTICALS CO., LTD (KR) | 2008-05-13 | — | — | US | disclosed |
| US-7371775-B2 | 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone monohydrate, the preparation method and uses thereof | DONG-A PHARMACEUTICALS CO., LTD (KR) | 2008-05-13 | — | — | US | disclosed |
| EP-0915864-B1 | GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE | DONG A PHARM CO LTD (KR) | 2002-09-04 | — | — | EP | disclosed |
| US-6025387-A | Gastroprotective flavone/flavanone compounds with therapeutic effect on inflammatory bowel disease | DONG A PHARMACEUTICAL CO., LTD. (KR) | 2000-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150196529-A1 | USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS | CYP2D6, GATAD2A, CYP3A43 | CYP1B1 135/4885POLH 4158/4885CYP1A1 59/4885 |
| US-20100130448-A1 | 3',4',5-TRIMETHOXY FLAVONE DERIVATIVES AS STIMULATN OF MUCUS SECRETION, METHOD FOR THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | TLR5, PTN, TSLP | CYP1B1 2614/4885POLH 4231/4885CYP1A1 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.