PTN — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13431410	0.72	2/20
SCHEMBL13431419	0.72	2/20
SCHEMBL13596864	0.72	2/20
SCHEMBL13431408	0.71	2/20
SCHEMBL13431409	0.70	2/20
SCHEMBL13431418	0.70	2/20
SCHEMBL13431469	0.70	2/20
SCHEMBL13431406	0.69	2/20
SCHEMBL14208653	0.65	2/20
SCHEMBL13431399	0.65	2/20
SCHEMBL18914908	0.64	2/20
SCHEMBL17167232	0.61	2/20
SCHEMBL13321926	0.61	2/20
SCHEMBL13321885	0.61	2/20
SCHEMBL13431412	0.61	2/20
SCHEMBL13431415	0.61	2/20
SCHEMBL13431465	0.61	2/20
SCHEMBL13321878	0.61	2/20
SCHEMBL13431401	0.60	2/20
SCHEMBL13431404	0.60	2/20

Clinical trials — most relevant to PTN by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease	PHASE4	COMPLETED
A Study Evaluating Megestrol Acetate Modulation in Hormone Receptor Positive Advanced Breast Cancer	PHASE2	UNKNOWN
Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis	PHASE2	COMPLETED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
Part 2 of Phase 1 Study of GC1008 to Treat Advanced Melanoma (Part 2 Will Only Accept and Treat Patients With Advanced Malignant Melanoma)	PHASE1	COMPLETED
Pharmacodynamics of CNP During Growth Hormone Treatment	nan	COMPLETED
The Role of Platelet Rich Plasma Injections in Cases of Stress Incontinence	nan	COMPLETED
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke	nan	UNKNOWN
Whole Gut Microbiome Sequencing in Patients With Anorexia Nervosa	nan	COMPLETED
Improvement of DIAgnostic and Phenotype-genotype Correlation Studies in Patients With MYOpathy Suspected of TITinopathy	nan	UNKNOWN
Uncovering an Electrical Biomarker for Freezing of Gait in Parkinson's Disease	nan	COMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism	nan	UNKNOWN
Uterine Cavity Assessment and Endometrial Gene Expression in Tamoxifen Treated Breast Cancer Patients	nan	UNKNOWN
The Role of Connective Tissue Growth Factor in the Development of Kidney Disease After Organ Transplantation	nan	COMPLETED
A Prospective Translational Tissue Collection Study in Early and Advanced Pancreatic Ductal Adenocarcinoma and Pancreatic Neuroendocrine Tumours to Enable Further Disease Characterisation and the Development of Potential Predictive and Prognostic Biomarkers	nan	UNKNOWN
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Osteocrin and Vascular Complications	nan	UNKNOWN
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Effect of Smoking on Periodontal Therapy in Periodontitis	nan	COMPLETED
Novel Biomarkers of Preeclampsia, Aquaporin, Fatty Acid, and S110B	nan	COMPLETED
Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study	nan	NOT_YET_RECRUITING
Serum Preptin Level and Its Relationship With Bone Mineral Disease in Chronic Kidney Disease Patients	nan	NOT_YET_RECRUITING
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity	nan	RECRUITING
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Identification of Spontaneous Delivery Markers	nan	COMPLETED
Development of a Wearable Device for Osteoporosis Prevention and Fracture Risk Reduction in Women	nan	ENROLLING_BY_INVITATION
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Platelet Rich Plasma for Uterine Scar	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PTN binder may also engage these)

Protein	Name	Similarity
P63089	—	1.000	P63089 →
P21782	—	1.000	P21782 →
P79281	—	1.000	P79281 →
P63090	—	1.000	P63090 →
P32760	—	0.993	P32760 →
P48532	—	0.973	P48532 →
P48533	—	0.969	P48533 →
Q90YC9	—	0.937	Q90YC9 →
Q6V9H4	—	0.936	Q6V9H4 →
Q9QYV1	—	0.935	Q9QYV1 →
Q925I7	—	0.934	Q925I7 →
Q17QD6	—	0.934	Q17QD6 →
O62650	—	0.934	O62650 →
P31514	—	0.934	P31514 →
O95980	—	0.934	O95980 →
A5YT95	—	0.933	A5YT95 →
P21674	—	0.933	P21674 →
Q9EQT1	—	0.933	Q9EQT1 →
P97401	—	0.931	P97401 →
Q8BFR2	—	0.931	Q8BFR2 →
Q9QYM9	—	0.930	Q9QYM9 →
Q9HAJ7	—	0.930	Q9HAJ7 →
Q9UIK5	—	0.930	Q9UIK5 →
SFRP1	Secreted frizzled-related protein 1	0.929	landscape →
Q90844	—	0.929	Q90844 →
Q6PFE7	—	0.929	Q6PFE7 →
P13213	—	0.929	P13213 →
Q86V25	—	0.928	Q86V25 →
Q8IYR6	—	0.928	Q8IYR6 →
Q8R4I7	—	0.928	Q8R4I7 →