Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 6/20 | 0.34 |
| ▸ | CCNC | P24863 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377176 | 1.00 | OTUD7B (0.50) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL16750994 | 0.93 | OTUD7B (0.42) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL20414626 | 0.89 | OTUD7B (0.57) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL13879320 | 0.89 | OTUD7B (0.57) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL22172615 | 0.89 | OTUD7B (0.57) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL25049525 | 0.84 | USP2 (0.34) | OTUD7BUSP2CYP2D6CYP2C9TSHR | |
| SCHEMBL26374604 | 0.84 | USP2 (0.34) | OTUD7BUSP2CYP2D6CYP2C9TSHR | |
| SCHEMBL23260107 | 0.83 | OTUD7B (0.49) | OTUD7BGRIN1GRIN2AGRIN2BCDK8 | |
| SCHEMBL23707125 | 0.79 | OTUD7B (0.50) | OTUD7BGRIN1GRIN2AGRIN2BACACB | |
| SCHEMBL23707127 | 0.79 | OTUD7B (0.50) | OTUD7BGRIN1GRIN2AGRIN2BACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548890-B1 | HPK1 antagonists and uses thereof | Nimbus Saturn, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548890-B1 | HPK1 antagonists and uses thereof | PDXK, HIPK1, PCK1 | OTUD7B 805/4885GRIN1 3676/4885GRIN2A 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.