Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317236 | 0.88 | L3MBTL1 (0.56) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2490286 | 0.88 | L3MBTL1 (0.56) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2485106 | 0.87 | ADORA3 (0.57) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL27838817 | 0.85 | NPSR1 (0.55) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2487161 | 0.83 | ADORA3 (0.55) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2316301 | 0.77 | ADORA3 (0.56) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2486141 | 0.76 | LMNA (0.52) | SMN1; SMN2HTTMAPTLMNAKMT2A | |
| SCHEMBL2319346 | 0.74 | ADORA3 (0.65) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL3185942 | 0.74 | ADORA3 (0.70) | ADORA3SMN1; SMN2NPSR1HTTMAPT | |
| SCHEMBL2317625 | 0.73 | ADORA3 (0.53) | ADORA3SMN1; SMN2NPSR1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |