Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13713493 | 0.82 | OPRM1 (0.43) | SMN1; SMN2P2RX7RAB9AOPRM1KDM4E | |
| SCHEMBL21993660 | 0.79 | TP53 (0.39) | SMN1; SMN2P2RX7RAB9AOPRM1KDM4E | |
| SCHEMBL6482424 | 0.79 | RAB9A (0.40) | SMN1; SMN2P2RX7RAB9AOPRM1MEN1 | |
| SCHEMBL8234459 | 0.78 | P2RX7 (0.38) | SMN1; SMN2P2RX7RAB9AOPRM1KDM4E | |
| SCHEMBL24864151 | 0.77 | PTPN1 (0.32) | OPRM1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL20909909 | 0.76 | RAB9A (0.43) | SMN1; SMN2P2RX7RAB9AMEN1KMT2A | |
| SCHEMBL15174120 | 0.76 | RAB9A (0.43) | SMN1; SMN2P2RX7RAB9AKDM4EMEN1 | |
| SCHEMBL9665431 | 0.75 | RAB9A (0.42) | SMN1; SMN2P2RX7RAB9AMEN1KMT2A | |
| SCHEMBL22781107 | 0.73 | HDAC6 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1HDAC6 | |
| SCHEMBL13713005 | 0.72 | RAB9A (0.40) | SMN1; SMN2P2RX7RAB9AOPRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230010358-A1 | Spiro-Sulfonamide Derivatives As Inhibitors Of Myeloid Cell Leukemia-1 (MCL-1) Protein | PRELUDE THERAPEUTICS, INCORPORATED | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010358-A1 | Spiro-Sulfonamide Derivatives As Inhibitors Of Myeloid Cell Leukemia-1 (MCL-1) Protein | MCL1, BCL2A1, BCL2L1 | SMN1; SMN2 2356/4885FAAH 4644/4885P2RX7 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.